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BQCA (synthétique) ≥97% (par HPLC)

Fournisseur: Enzo Life Sciences
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ALEXBML-C121-0010EA 0 CHF
ALEXBML-C121-0010 ALEXBML-C121-0050
BQCA (synthétique) ≥97% (par HPLC)
BQCA

Acetylcholine receptor activator.


Highly selective allosteric potentiator of the M₁ muscarinic acetylcholine receptor (mAChR). Reduces the concentration of ACh required to activate M₁ up to 129-fold and displays no potentiation, agonism or antagonism activity at other mAChRs at concentrations up to 100 µM. Reverses scopolamine-induced memory deficits and increases blood flow to the cerebral cortex in mouse models.


M₁ activators slow the progression of Alzheimer's disease. Induces β-arrestin recruitment to M₁. At 100 µM, it activated M₁ in the absence of ACh to ca. 50% maximal response. At 10 µM, it reduced the concentration of ACh required to displace radioligand by 45-fold. In vivo experiments were carried out in mice at 15 or 20 mg/kg. The compound is cell permeable, brain penetrant and orally active.


Soluble in DMSO (10 mg/ml).

Formule: C₁₈H₁₅NO₄
MW: 309,3 g/mol
MDL Number: MFCD01315710
Numéro CAS: 338747-41-4

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Résultats des tests de spécification

Source Synthetic
Purity ≥97% (HPLC)

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