Imprimer

Lactacystin

Fournisseur: Enzo Life Sciences

ALEXBML-PI104-0200EA 0 CHF
ALEXBML-PI104-0200 ALEXBML-PI104-1000
Lactacystin
Lactacystin

Key inhibitor for use in proteasome research.


A potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex). Blocks proteasome activity by targeting the catalytic beta-subunit. Has no effect on serine or cysteine proteases. Induces apoptosis inhuman monoblast U937 cells. Inhibits NF-kappaB activation by inhibiting IkappaB degradation (IC50=10 µM). Inhibits the ubiquitin proteasome pathway in cell culture. Inhibits cathepsin A. Upregulates HSP70 and HSP22, suggesting an initial neuroprotective pathway. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells.


Synthetic

Formule: C₁₅H₂₄N₂O₇S
Numéro CAS: 133343-34-7

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