Imprimer

Lactacystin (indigène) ≥97% (par HPLC)

ALEXALX350245MC01EA 173 CHF
ALEXALX350245MC01 ALEXALX350245M001
Lactacystin (indigène) ≥97% (par HPLC)
Lactacystin

Proteasome inhibitor


Cell permeable and irreversible proteasome inhibitor. Specifically inhibits 26S proteasome (MCP; multicatalytic proteinase complex). Blocks proteasome activity by targeting the catalytic beta-subunit. Has no effect on serine or cysteine proteases. Induces apoptosis in human monoblast U937 cells. Also inhibits NF-kappaB activation by inhibiting IkappaB degradation. Inhibits the ubiquitin proteasome pathway in cell culture (IC50=10µM). Inhibits cathepsin A. Upregulates HSP70 and HSP22, suggesting an initial neuroprotective pathway.


Isolated from Streptomyces sp.

Formule: C₁₅H₂₄N₂O₇S
Numéro CAS: 133343-34-7

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