Imprimer

BIOV2566

BIOV2566-1000EA 235 CHF
BIOV2566-1000 BIOV2566-500
BIOV2566
A potent and selective inhibitor of NEDD8 (Neural precursor cell expressed, developmentally down-regulated 8)-activating enzyme (NAE) (IC50 = 4,7 nM) with potential anticancer activity. NAE activates NEDD8, an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP). Supresses the growth of tumor xenografts in mice.

Soluble in DMSO (~10 mg/ml)
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