Getting the best out of solid core technology for small and large molecule analysis
The growth of solid core particle technology in liquid chromatography has seen an increase in the applicability of these types of particles to a wider range of workflow solutions, including the separation of large biomolecules. Additionally, there has also been an increase in the diversity of stationary phases available to the separation scientist. This presentation will begin by reviewing some of the fundamental benefits of solid core technology, moving onto how to best utilise the new technology.
We will discuss:
- Impact of different pore sizes and pore volumes on separation performance and loading capacity
- Separations, including intact and partially digested mAbs as well as full tryptic digests
- Troubleshooting aspects including the impact of flow rate on method transfer
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